JCCVS

Journal of Cardiology & Cardiovascular Surgery scientific, open-access, double-blind peer-reviewed journal covering a wide spectrum of topics in cardiology and cardiovascular surgery.

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Case Report
Cyclosporine induced bradycardia: is it rarely seen?
Immunosuppressive patients experience various side effects from their treatment. Cyclosporine is a commonly prescribed immunomodulatory agent with an increasing clinical applications. Although most common documented side effect is nephropathy, it can cause some cardiac side effects. This report presents a rare side effect of cyclosporine; bradycardia attacks in an immunosuppressed patient.


1. Tedesco D, Haragsim L. Cyclosporine: a review. J Transplant.2012;2012:230386. doi:10.1155/2012/230386
2. Fahr A. Cyclosporin clinical pharmacokinetics. Clin Pharmacokinet.1993;24(6):472-95. doi: 10.2165/00003088-199324060-00004. PMID:8513650.
3. Textor SC, Canzanello VJ, Taler SJ, Wilson DJ, Schwartz LL, AugustineJE et al. Cyclosporine-induced hypertension after transplantation. MayoClin Proc. 1994;69(12):1182-1193. doi:10.1016/s0025-6196(12)65772-3
4. Fujisaki G, Kami M, Murashige N, Kishi Y, Inokuchi C, Tanosaki R etal. Sinus bradycardia associated with cyclosporine following allogeneichematopoietic stem cell transplantation. Bone Marrow Transplant.2005;35(2):211-212. doi:10.1038/sj.bmt.1704747
5. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA et al. Amethod for estimating the probability of adverse drug reactions. ClinPharmacol Ther. 1981;30(2):239-245. doi:10.1038/clpt.1981.154
6. United States Food and Drug Administration. Adverse Event ReportingSystem Database (FAERS). https://fis.fda.gov/sense/app/95239e26-e0be-42d9-a960-9a5f 7f1c25ee/sheet/6b5a135f-f451-45be-893d-20aaee34e28e/state/analysis. Published 2017. Accessed November 3,2021.
7. Fujisaki G, Kami M, Murashige N, et al. Sinus bradycardia associatedwith cyclosporine following allogeneic hematopoietic stem celltransplantation. Bone Marrow Transplant. 2005;35(2):211-212.doi:10.1038/sj.bmt.1704747
8. El-Mas MM, Afify EA, Omar AG, Sharabi FM. Cyclosporine adverselyaffects baroreflexes via inhibition of testosterone modulation of cardiacvagal control. J Pharmacol Exp Ther. 2002;301(1):346-354. doi:10.1124/jpet.301.1.346
9. Miller LW. Cardiovascular toxicities of immunosuppressive agents.Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg.2002;2(9):807-818. doi:10.1034/j.1600-6143.2002.20902.x
Volume 1, Issue 1, 2023
Page : 16-18
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